Colon Tissue Homogenizer & Homogenization Protocol

Ideal for Colon Tissue Homogenization

Do you spend lots of time and effort homogenizing Colon tissue samples? The Bullet Blender® tissue homogenizer delivers high quality and superior yields. No other homogenizer comes close to delivering the Bullet Blender’s winning combination of top-quality performance and budget-friendly affordability. See below for a colon tissue homogenizer protocol.

The Bullet Blender® Homogenizer
Save Time, Effort and Get Superior Results

  • Consistent and High Yield Results
    Run up to 24 samples at the same time under microprocessor-controlled conditions, ensuring experimental reproducibility and high yield. Process samples from 10mg or less up to 3.5g.
  • No Cross Contamination
    No part of the Bullet Blender® ever touches the colon samples – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.
  • Samples Stay Cool
    Homogenizing causes only a few degrees of heating. The “Blue” model comes with a fan to maintain ambient temperatures, and the “Gold” model comes with a dry ice compartment to keep your samples at 4C.
  • Easy and Convenient to Use
    Just place beads and buffer along with your colon sample in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.
  • Risk Free Purchase
    The Bullet Blender® comes with a 30 day money back guarantee and a 2 year warranty, with a 3 year warranty on the motor. The simple, reliable design enables the Bullet Blenders to sell for a fraction of the price of ultrasonic or other agitation based instruments, yet provides an easier, quicker technique.
Bullet Blender Homogenizer

Bullet Blender Homogenization Protocol for Colon Tissue

Sample size

See the Protocol

microcentrifuge tube model (up to 300 mg) Small colon samples
5mL tube model (100mg – 1g) Medium colon samples


Selected Publications for Colon Tissue

See all of our Bullet Blender publications!

Lei, S., Ryu, J., Wen, K., Twitchell, E., Bui, T., Ramesh, A., Weiss, M., Li, G., Samuel, H., Clark-Deener, S., Jiang, X., Lee, K., & Yuan, L. (2016). Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency. Scientific Reports, 6.
Lei, S., Samuel, H., Twitchell, E., Bui, T., Ramesh, A., Wen, K., Weiss, M., Li, G., Yang, X., Jiang, X., & Yuan, L. (2016). Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs. Scientific Reports, 6.
Bennike, T. B., Kastaniegaard, K., Padurariu, S., Gaihede, M., Birkelund, S., Andersen, V., & Stensballe, A. (2016). Proteome stability analysis of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human colon mucosal biopsies. Data in Brief, 6, 942–947.
Bennike, T. B., Kastaniegaard, K., Padurariu, S., Gaihede, M., Birkelund, S., Andersen, V., & Stensballe, A. (2016). Comparing the proteome of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human tissue samples. EuPA Open Proteomics, 10, 9–18.
Park, W. C., Kim, H.-R., Kang, D. B., Ryu, J.-S., Choi, K.-H., Lee, G.-O., Yun, K. J., Kim, K. Y., Park, R., Yoon, K.-H., Cho, J.-H., Lee, Y.-J., Chae, S.-C., Park, M.-C., & Park, D.-S. (2016). Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer. BMC Cancer, 16, 358.
Falendysz, E. A., Lopera, J. G., Lorenzsonn, F., Salzer, J. S., Hutson, C. L., Doty, J., Gallardo-Romero, N., Carroll, D. S., Osorio, J. E., & Rocke, T. E. (2015). Further Assessment of Monkeypox Virus Infection in Gambian Pouched Rats (Cricetomys gambianus) Using In Vivo Bioluminescent Imaging. PLOS Neglected Tropical Diseases, 9(10), e0004130.
Capitán-Cañadas, F., Ocón, B., Aranda, C. J., Anzola, A., Suárez, M. D., Zarzuelo, A., de Medina, F. S., & Martínez-Augustin, O. (2015). Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4+ CD62L+ T cell transfer model of colitis in C57BL/6J mice. European Journal of Nutrition.
Everman, J. L., Eckstein, T. M., Roussey, J., Coussens, P., Bannantine, J. P., & Bermudez, L. E. (2015). Characterization of the inflammatory phenotype of Mycobacterium avium subspecies paratuberculosis using a novel cell culture passage model. Microbiology, 161(7), 1420–1434.
Danan-Gotthold, M., Golan-Gerstl, R., Eisenberg, E., Meir, K., Karni, R., & Levanon, E. Y. (2015). Identification of recurrent regulated alternative splicing events across human solid tumors. Nucleic Acids Research, 43(10), 5130–5144.
Choong, E., Guo, J., Persson, A., Virding, S., Johansson, I., Mkrtchian, S., & Ingelman-Sundberg, M. (2015). Developmental Regulation and Induction of Cytochrome P450 2W1, an Enzyme Expressed in Colon Tumors. PLOS ONE, 10(4), e0122820.
Zhou, Y., Rychahou, P., Wang, Q., Weiss, H. L., & Evers, B. M. (2015). TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium. Cell Death and Disease, 6(2), e1631.
Doldur-Balli, F., Ozel, M. N., Gulsuner, S., Tekinay, A. B., Ozcelik, T., Konu, O., & Adams, M. M. (2015). Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ). BMC Neuroscience, 16(1).
Janocko, L., Althouse, A. D., Brand, R. M., Cranston, R. D., & McGowan, I. (2015). The Molecular Characterization of Intestinal Explant HIV Infection Using Polymerase Chain Reaction-Based Techniques. AIDS Research and Human Retroviruses, 31(10), 981–991.
Wang, Y.-M., Chai, S. C., Lin, W., Chai, X., Elias, A., Wu, J., Ong, S. S., Pondugula, S. R., Beard, J. A., Schuetz, E. G., Zeng, S., Xie, W., & Chen, T. (2015). Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. Biochemical Pharmacology, 96(4), 357–368.
Eriksson, A., Williams, M. J., Voisin, S., Hansson, I., Krishnan, A., Philippot, G., Yamskova, O., Herisson, F. M., Dnyansagar, R., Moschonis, G., Manios, Y., Chrousos, G. P., Olszewski, P. K., Frediksson, R., & Schiöth, H. B. (2015). Implication of coronin 7 in body weight regulation in humans, mice and flies. BMC Neuroscience, 16(1), 13.
Liu, G., Yan, T., Fang, T., Jia, G., Chen, X., Zhao, H., Wang, J., & Wu, C. (2015). Nutrimetabolomic analysis provides new insights into spermine-induced ileum-system alterations for suckling rats. RSC Adv., 5(60), 48769–48778.
Goodrich, K. M., Dorenkott, M. R., Ye, L., O’Keefe, S. F., Hulver, M. W., & Neilson, A. P. (2014). Dietary Supplementation with Cocoa Flavanols Does Not Alter Colon Tissue Profiles of Native Flavanols and Their Microbial Metabolites Established during Habitual Dietary Exposure in C57BL/6J Mice. Journal of Agricultural and Food Chemistry, 62(46), 11190–11199.
Mapes, B., Chase, M., Hong, E., Ludvik, A., Ceryes, K., Huang, Y., & Kupfer, S. S. (2014). Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1 ,25(OH)2 and 25(OH) vitamin D. Physiological Genomics, 46(8), 302–308.
van der Plas-Duivesteijn, S. J., Mohammed, Y., Dalebout, H., Meijer, A., Botermans, A., Hoogendijk, J. L., Henneman, A. A., Deelder, A. M., Spaink, H. P., & Palmblad, M. (2014). Identifying Proteins in Zebrafish Embryos Using Spectral Libraries Generated from Dissected Adult Organs and Tissues. Journal of Proteome Research, 13(3), 1537–1544.
Mascaraque, C., Aranda, C., Ocón, B., Monte, M. J., Suárez, M. D., Zarzuelo, A., Marín, J. J. G., Martínez-Augustin, O., & de Medina, F. S. (2014). Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis. Pharmacological Research, 90, 48–57.
Borschensky, C. M., & Reinacher, M. (2014). Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats. Research in Veterinary Science, 97(2), 333–340.
Heinzerling, N. P., Liedel, J. L., Welak, S. R., Fredrich, K., Biesterveld, B. E., Pritchard, K. A., & Gourlay, D. M. (2014). Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. Journal of Pediatric Surgery, 49(6), 954–960.
Goodrich, K. M., & Neilson, A. P. (2014). Simultaneous UPLC–MS/MS analysis of native catechins and procyanidins and their microbial metabolites in intestinal contents and tissues of male Wistar Furth inbred rats. Journal of Chromatography B, 958, 63–74.
Melero, M., García-Párraga, D., Corpa, J., Ortega, J., Rubio-Guerri, C., Crespo, J., Rivera-Arroyo, B., & Sánchez-Vizcaíno, J. (2014). First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens). BMC Veterinary Research, 10(1), 968.
Naba, A., Clauser, K. R., Whittaker, C. A., Carr, S. A., Tanabe, K. K., & Hynes, R. O. (2014). Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer, 14(1), 518.
Kovalenko, P. L., Yuan, L., Sun, K., Kunovska, L., Seregin, S., Amalfitano, A., & Basson, M. D. (2013). Regulation of Epithelial Differentiation in Rat Intestine by Intraluminal Delivery of an Adenoviral Vector or Silencing RNA Coding for Schlafen 3. PLoS ONE, 8(11), e79745.
Rubio-Guerri, C., Melero, M., Esperón, F., Bellière, E., Arbelo, M., Crespo, J., Sierra, E., García-Párraga, D., & Sánchez-Vizcaíno, J. (2013). Unusual striped dolphin mass mortality episode related to cetacean morbillivirus in the Spanish Mediterranean sea. BMC Veterinary Research, 9(1), 106.
Araújo-Pérez, F., McCoy, A. N., Okechukwu, C., Carroll, I. M., Smith, K. M., Jeremiah, K., Sandler, R. S., Asher, G. N., & Keku, T. O. (2012). Differences in microbial signatures between rectal mucosal biopsies and rectal swabs. Gut Microbes, 3(6), 530–535.
Kovalenko, P. L., Flanigan, T. L., Chaturvedi, L., & Basson, M. D. (2012). Influence of defunctionalization and mechanical forces on intestinal epithelial wound healing. AJP: Gastrointestinal and Liver Physiology, 303(10), G1134–G1143.
Kovalenko, P. L., Kunovska, L., Chen, J., Gallo, K. A., & Basson, M. D. (2012). Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa. AJP: Gastrointestinal and Liver Physiology, 303(8), G951–G960.
Forester, S. C., Gu, Y., & Lambert, J. D. (2012). Inhibition of starch digestion by the green tea polyphenol, (−)-epigallocatechin-3-gallate. Molecular Nutrition & Food Research, 56(11), 1647–1654.
Kovalenko, P. L., & Basson, M. D. (2012). Changes in morphology and function in small intestinal mucosa after Roux-en-Y surgery in a rat model. Journal of Surgical Research, 177(1), 63–69.
Shaw, A. L., van Ginkel, F. W., Macklin, K. S., & Blake, J. P. (2011). Effects of phytase supplementation in broiler diets on a natural Eimeria challenge in naive and vaccinated birds. Poultry Science, 90(4), 781–790.
Lowe, E. L., Crother, T. R., Rabizadeh, S., Hu, B., Wang, H., Chen, S., Shimada, K., Wong, M. H., Michelsen, K. S., & Arditi, M. (2010). Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer. PLoS ONE, 5(9), e13027.
Lancaster, K. Z., & Pfeiffer, J. K. (2010). Limited Trafficking of a Neurotropic Virus Through Inefficient Retrograde Axonal Transport and the Type I Interferon Response. PLoS Pathogens, 6(3), e1000791.
Lu, J., & Grenache, D. G. (2010). High-throughput tissue homogenization method and tissue-based quality control materials for a clinical assay of the intestinal disaccharidases. Clinica Chimica Acta, 411(9–10), 754–757.
Xiao, L., Cao, W., Liu, G., Fang, T., Wu, X., Jia, G., Chen, X., Zhao, H., Wang, J., Wu, C., & Cai, J. (n.d.). Arginine, N-carbamylglutamate, and glutamine exert protective effects against oxidative stress in rat intestine. Animal Nutrition.
Jensen, A. R., Manning, M. M., Khaneki, S., Drucker, N. A., & Markel, T. A. (n.d.). Harvest tissue source does not alter the protective power of stromal cell therapy after intestinal ischemia and reperfusion injury. Journal of Surgical Research.

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