Chemical extraction homogenization

Ideal for Chemical Extraction

Save Time, Effort and Get Superior Results with

Bullet Blender Homogenizer
  • Consistent Results
  • Samples Stay Cool
  • No Cross Contamination
  • Easy and Convenient
  • Risk Free
Bullet Blender
Ideal preparation for chemical analysis including activity assays, gas chromatography, mass spectrometry, Western Blots, Southern Blots, ELISA, HPLC, UPLC, GC-MS, liquid chromatography, LC-MS, LC-UV-MS, purification, lipid or protein extraction, drug detection, and forensic analysis.Do you spend lots of time and effort homogenizing samples to extract chemicals? The Bullet Blender® is a multi-sample homogenizer that delivers superior results. No other homogenizer comes close to delivering the Bullet Blender’s winning combination of top-quality performance and budget-friendly affordability.
  • Consistent and High Yield Results
    Run up to 24 samples at the same time under microprocessor-controlled conditions, ensuring experimental reproducibility and high yield. Process samples from 10mg or less up to 3.5g.
  • No Cross Contamination
    No part of the Bullet Blender® ever touches the sample – the sample tubes are kept closed during homogenization. There are no probes to clean between samples.
  • Samples Stay Cool
    Homogenizing causes only a few degrees of heating. Our “Blue” model comes with a fan to maintain ambient temperatures.
  • Easy and Convenient to Use
    Just place beads and buffer along with your sample in standard tubes, load tubes directly in the Bullet Blender, select time and speed, and press start.
  • Risk Free Purchase
    The Bullet Blender® comes with a 30 day money back guarantee and a 2 year warranty, with a 3 year warranty on the motor. The simple, reliable design enables the Bullet Blenders to sell for a fraction of the price of ultrasonic or other agitation based instruments, yet provides an easier, quicker technique.



Example protocols for Chemical Extraction

Small molecules can be extracted from almost any sample type using the Bullet Blender. See our Protocols page for the full list.

Sample size

See the Protocol

microcentrifuge tube model (up to 300 mg) Small samples of powdered compounds
50mL tube model (100mg – 3.5g) Large pills/tablets


Selected publications for Chemical Extraction

See all of our Bullet Blender publications!

Rasool, A., Ahmed, M. S., & Li, C. (2016). Overproduction of squalene synergistically downregulates ethanol production in Saccharomyces cerevisiae. Chemical Engineering Science, 152, 370–380.
Zhou, Y., Bennett, T. M., & Shiels, A. (2016). Lens ER-stress response during cataract development in Mip-mutant mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(8), 1433–1442.
Rubinchik-Stern, M., Shmuel, M., Bar, J., Eyal, S., & Kovo, M. (2016). Maternal–fetal transfer of indocyanine green across the perfused human placenta. Reproductive Toxicology, 62, 100–105.
Chen, I.-T., Lee, D.-Y., Huang, Y.-T., Kou, G.-H., Wang, H.-C., Chang, G.-D., & Lo, C.-F. (2016). Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Host’s Oxidative Stress Defenses. Scientific Reports, 6, 27732.
Miranda, C. L., Elias, V. D., Hay, J. J., Choi, J., Reed, R. L., & Stevens, J. F. (2016). Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Archives of Biochemistry and Biophysics, 599, 22–30.
Riga, P., Benedicto, L., García-Flores, L., Villaño, D., Medina, S., & Gil-Izquierdo, Á. (2016). Rootstock effect on serotonin and nutritional quality of tomatoes produced under low temperature and light conditions. Journal of Food Composition and Analysis, 46, 50–59.
Wen, L., Gao, Q., Ma, C., Ge, Y., You, L., Liu, R. H., Fu, X., & Liu, D. (2016). Effect of polysaccharides from Tremella fuciformis on UV-induced photoaging. Journal of Functional Foods, 20, 400–410.
Adamo, R. F., Fishbein, I., Zhang, K., Wen, J., Levy, R. J., Alferiev, I. S., & Chorny, M. (2016). Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of Controlled Release, 222, 169–175.
Marin, S. J., & McMillin, G. A. (2016). Quantitation of Total Buprenorphine  and Norbuprenorphine in Meconium by LC-MS/MS. In Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols (Vol. 1383, pp. 59–68). Springer Science+Business Media.
Hajkova, K., Jurasek, B., Sykora, D., Palenicek, T., Miksatkova, P., & Kuchar, M. (2015). Salting-out-assisted liquid–liquid extraction as a suitable approach for determination of methoxetamine in large sets of tissue samples. Analytical and Bioanalytical Chemistry.
Glatz, A., Pilbat, A.-M., Németh, G. L., Vince-Kontár, K., Jósvay, K., Hunya, Á., Udvardy, A., Gombos, I., Péter, M., Balogh, G., Horváth, I., Vígh, L., & Török, Z. (2015). Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe. Cell Stress and Chaperones.
Mattsson, A., Kärrman, A., Pinto, R., & Brunström, B. (2015). Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors. PLOS ONE, 10(12), e0143780.
Rand, M. D., Vorojeikina, D., van Wijngaarden, E., Jackson, B. P., Scrimale, T., Zareba, G., Love, T. M., Myers, G. J., & Watson, G. E. (2015). Methods for Individualized Determination of Methylmercury Elimination Rate and De-Methylation Status in Humans Following Fish Consumption. Toxicological Sciences, kfv241.
Prasain, J., Wilson, L., Hoang, H., Moore, R., & Miller, M. (2015). Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry. Metabolites, 5(4), 677–696.
Shokati, T., Bodenberger, N., Gadpaille, H., Schniedewind, B., Vinks, A. A., Jiang, W., Alloway, R. R., & Christians, U. (2015). Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. Journal of Visualized Experiments, 105.
Ruhaak, L. R., Taylor, S. L., Stroble, C., Nguyen, U. T., Parker, E. A., Song, T., Lebrilla, C. B., Rom, W. N., Pass, H., Kim, K., Kelly, K., & Miyamoto, S. (2015). Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue. Journal of Proteome Research, 14(11), 4538–4549.
Lee, M., Chen, Z., Tomlinson, B. N., Gooyit, M., Hesek, D., Juárez, M. R., Nizam, R., Boggess, B., Lastochkin, E., Schroeder, V. A., Wolter, W. R., Suckow, M. A., Cui, J., Mobashery, S., Gu, Z., & Chang, M. (2015). Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury. ACS Chemical Neuroscience, 6(10), 1658–1664.
Davis, T. S., Bosque-Pérez, N. A., Popova, I., & Eigenbrode, S. D. (2015). Evidence for additive effects of virus infection and water availability on phytohormone induction in a staple crop. Frontiers in Ecology and Evolution, 3.
Yau, B., Mitchell, A. J., Too, L. K., Ball, H. J., & Hunt, N. H. (2015). Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis. Journal of Interferon & Cytokine Research.
Otsubo, C., Bharathi, S., Uppala, R., Ilkayeva, O. R., Wang, D., McHugh, K., Zou, Y., Wang, J., Alcorn, J. F., Zuo, Y. Y., Hirschey, M. D., & Goetzman, E. S. (2015). Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. Journal of Biological Chemistry, 290(39), 23897–23904.
Kuo, Y.-H., Chen, C.-W., Chu, Y., Lin, P., & Chiang, H.-M. (2015). In Vitro and In Vivo Studies on Protective Action of N-Phenethyl Caffeamide against Photodamage of Skin. PLOS ONE, 10(9), e0136777.
Aylward, F. O., Khadempour, L., Tremmel, D. M., McDonald, B. R., Nicora, C. D., Wu, S., Moore, R. J., Orton, D. J., Monroe, M. E., Piehowski, P. D., Purvine, S. O., Smith, R. D., Lipton, M. S., Burnum-Johnson, K. E., & Currie, C. R. (2015). Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants. PLOS ONE, 10(8), e0134752.
Wang, Z., Neal, B. H., Lamb, J. C., & Klaunig, J. E. (2015). Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicological Sciences, kfv151.
Charbel Issa, P., Barnard, A. R., Herrmann, P., Washington, I., & MacLaren, R. E. (2015). Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization. Proceedings of the National Academy of Sciences, 112(27), 8415–8420.
Hurley-Sanders, J. L., Levine, J. F., Nelson, S. A. C., Law, J. M., Showers, W. J., & Stoskopf, M. K. (2015). Key metabolites in tissue extracts of Elliptio complanata identified using 1H nuclear magnetic resonance spectroscopy. Conservation Physiology, 3(1), cov023–cov023.
Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M.-A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., Ponnuswami, A., Chen, S., Johung, T. B., Sun, W., Kogiso, M., Du, Y., Qi, L., Huang, Y., Hütt-Cabezas, M., … Monje, M. (2015). Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature Medicine, 21(6), 555–559.
Kent, M., Welladsen, H. M., Mangott, A., & Li, Y. (2015). Nutritional Evaluation of Australian Microalgae as Potential Human Health Supplements. PLOS ONE, 10(2), e0118985.
Schisler, J. C., Grevengoed, T. J., Pascual, F., Cooper, D. E., Ellis, J. M., Paul, D. S., Willis, M. S., Patterson, C., Jia, W., & Coleman, R. A. (2015). Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin. Journal of the American Heart Association, 4(2), e001136–e001136.
Zhang, L., Gualberto, D. G., Guo, X., Correa, P., Jee, C., & Garcia, L. R. (2015). TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment. Nature Communications, 6, 6345.
Zheng, X., Reho, J. J., Wirth, B., & Fisher, S. A. (2015). TRA2β controls Mypt1 exon 24 splicing in the developmental maturation of mouse mesenteric artery smooth muscle. American Journal of Physiology - Cell Physiology, 308(4), C289–C296.
Adelaiye, R., Ciamporcero, E., Miles, K. M., Sotomayor, P., Bard, J., Tsompana, M., Conroy, D., Shen, L., Ramakrishnan, S., Ku, S.-Y., Orillion, A., Prey, J., Fetterly, G., Buck, M., Chintala, S., Bjarnason, G. A., & Pili, R. (2015). Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications. Molecular Cancer Therapeutics, 14(2), 513–522.
Gao, X., Yang, T., Liu, M., Peleli, M., Zollbrecht, C., Weitzberg, E., Lundberg, J. O., Persson, A. E. G., & Carlstrom, M. (2015). NADPH Oxidase in the Renal Microvasculature Is a Primary Target for Blood Pressure-Lowering Effects by Inorganic Nitrate and Nitrite. Hypertension, 65(1), 161–170.
Burrell-Saward, H. (2015). Development of an imaging model of a CNS infection with African trypanosomes. [London School of Hygeine and Tropical Medicine].
Pekar, H., Westerberg, E., Bruno, O., Lääne, A., Persson, K. M., Sundström, L. F., & Thim, A.-M. (2015). Fast, rugged and sensitive ultra high pressure liquid chromatography tandem mass spectrometry method for analysis of cyanotoxins in raw water and drinking water—First findings of anatoxins, cylindrospermopsins and microcystin variants in Swedish source waters and infiltration ponds. Journal of Chromatography A.
Yuan, Z.-X., & Rapoport, S. I. (2015). Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 101, 9–14.
Zhou, J., Coles, L. D., Kartha, R. V., Nash, N., Mishra, U., Lund, T. C., & Cloyd, J. C. (2015). Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status. Journal of Pharmaceutical Sciences, 104(8), 2619–2626.
Carlström, M., Liu, M., Yang, T., Zollbrecht, C., Huang, L., Peleli, M., Borniquel, S., Kishikawa, H., Hezel, M., Persson, A. E. G., Weitzberg, E., & Lundberg, J. O. (2015). Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. Antioxidants & Redox Signaling, 23(4), 295–306.
Elie, M. R., Choi, J., Nkrumah-Elie, Y. M., Gonnerman, G. D., Stevens, J. F., & Tanguay, R. L. (2015). Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environmental Research, 140, 502–510.
Tierno, R., López, A., Riga, P., Arazuri, S., Jarén, C., Benedicto, L., & Ruiz de Galarreta, J. I. (2015). Phytochemicals determination and classification in purple and red fleshed potato tubers by analytical methods and near infrared spectroscopy: Phytochemicals in potato tubers. Journal of the Science of Food and Agriculture, n/a-n/a.
Neishabouri, S. H., Hutson, S. M., & Davoodi, J. (2015). Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy. Amino Acids, 47(6), 1167–1182.
Allensworth, J. L., Evans, M. K., Bertucci, F., Aldrich, A. J., Festa, R. A., Finetti, P., Ueno, N. T., Safi, R., McDonnell, D. P., Thiele, D. J., Van Laere, S., & Devi, G. R. (2015). Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Molecular Oncology, 9(6), 1155–1168.
Li, Y., Xiao, G., Mangott, A., Kent, M., & Pirozzi, I. (2015). Nutrient efficacy of microalgae as aquafeed additives for the adult black tiger prawn, Penaeus monodon. Aquaculture Research, 46.
Goodrich, K. M., Smithson, A. T., Ickes, A. K., & Neilson, A. P. (2015). Pan-colonic pharmacokinetics of catechins and procyanidins in male Sprague–Dawley rats. The Journal of Nutritional Biochemistry.
Alves, R. D. A. M., Dane, A. D., Harms, A., Strassburg, K., Seifar, R. M., Verdijk, L. B., Kersten, S., Berger, R., Hankemeier, T., & Vreeken, R. J. (2015). Global profiling of the muscle metabolome: method optimization, validation and application to determine exercise-induced metabolic effects. Metabolomics, 11(2), 271–285.
Aryal, M., Vykhodtseva, N., Zhang, Y.-Z., & McDannold, N. (2015). Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood–brain barrier disruption: A safety study. Journal of Controlled Release, 204, 60–69.
Hao, L., Chen, W., McConnell, M., Zhu, Z., Li, S., Reddy, M., Eleazer, P. D., Wang, M., & Li, Y.-P. (2015). A Small Molecule, Odanacatib, Inhibits Inflammation and Bone Loss Caused by Endodontic Disease. Infection and Immunity, 83(4), 1235–1245.
Marshall, K. E., & Sinclair, B. J. (2015). The relative importance of number, duration and intensity of cold stress events in determining survival and energetics of an overwintering insect. Functional Ecology, 29(3), 357–366.
Jones, J. T., Jones, M., Jones, B., Sulaiman, K., Plate, C., & Lewis, D. (2015). Detection of Codeine, Morphine, 6-Monoacetylmorphine, and Meconin in Human Umbilical Cord Tissue: Method Validation and Evidence of In Utero Heroin Exposure. Therapeutic Drug Monitoring, 37(1), 45–52.
Liu, G., Yan, T., Fang, T., Jia, G., Chen, X., Zhao, H., Wang, J., & Wu, C. (2015). Nutrimetabolomic analysis provides new insights into spermine-induced ileum-system alterations for suckling rats. RSC Adv., 5(60), 48769–48778.
Yoshida, Y., Ozawa, T., Yao, T.-W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S.-Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T., & James, C. D. (2014). NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification. Molecular Cancer Therapeutics, 13(12), 2919–2929.